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سوماتواستاتين ، Somatostatin ، OCTREOTIDE برای کاهش ترشح هورمون رشد ودرمان اکرومگالی

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هورمون سوماتواستاتين

 

نام لاتین: OCTREOTIDE گروه دارویی: هورمون سوماتواستاتين گروه شیمیایی: آنالوگ هورمونى

مکانیسم اثر

هورمون سوماتواستاتين داراى اثرات مختلفى است از جمله کاهش ترشح هورمون رشد، گلوکاگون، انسولين، سروتونين و VIP؛ همچنين باعث افزايش زمان توقف روده‌اى مي‌شود.

سوماتواستاتین یا هورمون مهارکننده هورمون رشد (GHIH)، با تاثیر بر گیرنده‌های خود در هیپوفیز موجب مهار ترشح هورمون رشد و هورمون محرکه تیروئید می‌شود. هم‌چنین در دستگاه گوارش موجب مهار ترشح هورمونهای گاسترین، موتیلین، سکرتین،انسولین، کوله‌سیستوکینین، (VIP) و (GIP) خواهد شد.[۱] این هورمون موجب کندی حرکات روده میشود.

موارد مصرف

آکرومگالي، درمان علامتى سندرم کارسينوئيد (اسهال شديد و گرگرفتگي)، اسهال شديد ناشى از تومورهاى VIP ، شيم‌درماني، ايلنوستومي، ايدز.

میزان مصرف

بالغين: مقدار ۳۰۰ـ۲۰۰ mcg در ۲ دوز منقسم روزانه.
موارد منع مصرف: حساسيت به دارو.

عوارض جانبی

گوارشي: تهوع، استفراغ، نفخ شکم، هپاتيت.
دستگاه عصبي: سردرد، سرگيجه، احساس خستگي، ضعف، اضطراب، صرع.
قلبى ـ عروقي: آريتمي، هيپرتانسيون، ايسکمى عروقي، CHF.
ديگر موارد: افزايش فشار داخل چشمي، آسم، ژينکوماستي، گالاکتوره، عفونت، آنمي، ترومبوفلبيت.
مراقبت های لازم :
ـ اندازه‌گيرى هورمون رشد: در آکرومگالى قبل از شروع درمان و طى درمان در فواصل منظم.
ـ در سندرم کارسينوئيد: اندازه‌گيرى ۵HLAA, 5HT و ماده P.
ـ اندازه‌گيرى T4, TSH: و کنترل از نظر احتمال هيپوتيروئيدي.
ـ سطح سرمى کلسيم: از نظر احتمال هيپوو يا هيپرکلسمي.
ـ EKG: و مراقبت از نظر رويداد آريتمي.

References

  1. “Human PubMed Reference:”.
  2. Jump up^ “Mouse PubMed Reference:”.
  3. Jump up^ “somatostatin”. Encyclopædia Britannica. Encyclopædia Britannica Online. Encyclopædia Britannica Inc., 2016. Web. 04 mag. 2016 <http://www.britannica.com/science/somatostatin>.
  4. ^ Jump up to:a b Costoff A. “Sect. 5, Ch. 4: Structure, Synthesis, and Secretion of Somatostatin”. Endocrinology: The Endocrine Pancreas. Medical College of Georgia. p. ۱۶٫ Archived from the original on April 5, 2008. Retrieved 2008-02-19.
  5. Jump up^ somatostatin preproprotein [Homo sapiens] See Features
  6. ^ Jump up to:a b c Liu Y, Lu D, Zhang Y, Li S, Liu X, Lin H (2010). “The evolution of somatostatin in vertebrates”. Gene. 463 (1–۲): ۲۱–۲۸٫ PMID ۲۰۴۷۲۰۴۳. doi:10.1016/j.gene.2010.04.016.
  7. Jump up^ Gahete MD, Cordoba-Chacón J, Duran-Prado M, Malagón MM, Martinez-Fuentes AJ, Gracia-Navarro F, Luque RM, Castaño JP (2010). “Somatostatin and its receptors from fish to mammals”. Annals of the New York Academy of Sciences. 1200: 43–۵۲٫ PMID ۲۰۶۳۳۱۳۲. doi:10.1111/j.1749-6632.2010.05511.x.
  8. Jump up^ “Entrez Gene: Somatostatin”.
  9. Jump up^ Shen LP, Pictet RL, Rutter WJ (August 1982). “Human somatostatin I: sequence of the cDNA”. Proc. Natl. Acad. Sci. U.S.A. 79 (15): 4575–۹٫ PMC ۳۴۶۷۱۷Freely accessible. PMID ۶۱۲۶۸۷۵. doi:10.1073/pnas.79.15.4575.
  10. Jump up^ Shen LP, Rutter WJ (April 1984). “Sequence of the human somatostatin I gene”. Science. 224 (4645): 168–۷۱٫ PMID ۶۱۴۲۵۳۱. doi:10.1126/science.6142531.
  11. ^ Jump up to:a b c Boron, Walter F.; Boulpaep, Emile L. (2012). Medical Physiology, 2e Updated Edition, 2nd Edition (2nd ed.). Philadelphia, PA: Elsevier. ISBN ۹۷۸۱۴۳۷۷۱۷۵۳۲.
  12. ^ Jump up to:a b Bowen R (2002-12-14). “Somatostatin”. Biomedical Hypertextbooks. Colorado State University. Retrieved 2008-02-19.
  13. Jump up^ First Aid for the USMLE Step 1, 2010. Page 286.
  14. ^ Jump up to:a b Costoff A. “Sect. 5, Ch. 4: Structure, Synthesis, and Secretion of Somatostatin”. Endocrinology: The Endocrine Pancreas. Medical College of Georgia. p. ۱۷٫ Archived from the original on March 31, 2008. Retrieved 2008-02-19.
  15. Jump up^ Van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO (2016-06-15). “Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion”. Nature Medicine. 21: 769–۷۶٫

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