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سوماتواستاتين ، Somatostatin ، OCTREOTIDE برای کاهش ترشح هورمون رشد ودرمان اکرومگالی

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هورمون سوماتواستاتين


نام لاتین: OCTREOTIDE گروه دارویی: هورمون سوماتواستاتين گروه شیمیایی: آنالوگ هورمونى

مکانیسم اثر

هورمون سوماتواستاتين داراى اثرات مختلفى است از جمله کاهش ترشح هورمون رشد، گلوکاگون، انسولين، سروتونين و VIP؛ همچنين باعث افزايش زمان توقف روده‌اى مي‌شود.

سوماتواستاتین یا هورمون مهارکننده هورمون رشد (GHIH)، با تاثیر بر گیرنده‌های خود در هیپوفیز موجب مهار ترشح هورمون رشد و هورمون محرکه تیروئید می‌شود. هم‌چنین در دستگاه گوارش موجب مهار ترشح هورمونهای گاسترین، موتیلین، سکرتین،انسولین، کوله‌سیستوکینین، (VIP) و (GIP) خواهد شد.[۱] این هورمون موجب کندی حرکات روده میشود.

موارد مصرف

آکرومگالي، درمان علامتى سندرم کارسينوئيد (اسهال شديد و گرگرفتگي)، اسهال شديد ناشى از تومورهاى VIP ، شيم‌درماني، ايلنوستومي، ايدز.

میزان مصرف

بالغين: مقدار ۳۰۰ـ۲۰۰ mcg در ۲ دوز منقسم روزانه.
موارد منع مصرف: حساسيت به دارو.

عوارض جانبی

گوارشي: تهوع، استفراغ، نفخ شکم، هپاتيت.
دستگاه عصبي: سردرد، سرگيجه، احساس خستگي، ضعف، اضطراب، صرع.
قلبى ـ عروقي: آريتمي، هيپرتانسيون، ايسکمى عروقي، CHF.
ديگر موارد: افزايش فشار داخل چشمي، آسم، ژينکوماستي، گالاکتوره، عفونت، آنمي، ترومبوفلبيت.
مراقبت های لازم :
ـ اندازه‌گيرى هورمون رشد: در آکرومگالى قبل از شروع درمان و طى درمان در فواصل منظم.
ـ در سندرم کارسينوئيد: اندازه‌گيرى ۵HLAA, 5HT و ماده P.
ـ اندازه‌گيرى T4, TSH: و کنترل از نظر احتمال هيپوتيروئيدي.
ـ سطح سرمى کلسيم: از نظر احتمال هيپوو يا هيپرکلسمي.
ـ EKG: و مراقبت از نظر رويداد آريتمي.


  1. “Human PubMed Reference:”.
  2. Jump up^ “Mouse PubMed Reference:”.
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  15. Jump up^ Van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO (2016-06-15). “Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion”. Nature Medicine. 21: 769–۷۶٫


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